Topic 18 – Liver Diseases, Hepatitis, Drug Metabolism and Obstructive Jaundice

This topic uses the AIM Learning Cycle to help MBBS students understand pathological and clinical disorders affecting liver and biliary system.

1. Curriculum Coverage

Pathology

• Viruses causing acute hepatitis
• Viruses causing chronic hepatitis

• Pathogenesis of liver cirrhosis
• Stages of liver cirrhosis
• Clinical presentation of liver cirrhosis

Pharmacology

• Drug detoxification in liver
• Hepatic drug metabolism
• First-pass metabolism

• Hepatotoxic drugs
• Toxic effects of hepatotoxic drugs

Forensic Medicine

• Hepatotoxic poisons
• Toxicological sampling for poisoning

. Diagnosis of poisoning through routine toxicological sampling

Community Medicine

• Epidemiology of Hepatitis B
• Epidemiology of Hepatitis C
• Control measures of Hepatitis B and C

• Hepatitis A
• Hepatitis E
• Control of water-borne hepatitis

Medicine

• Etiology of liver cirrhosis
• Clinical features of liver cirrhosis
• Complications of liver cirrhosis
• Treatment of liver cirrhosis

Surgery

• Etiology of obstructive jaundice
• Clinical features of obstructive jaundice
• Biochemical investigations of obstructive jaundice
• Treatment of obstructive jaundice

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