This topic uses the AIM Learning Cycle to help MBBS students understand mitochondrial energy generation and ATP production.
Curriculum Coverage
Biochemistry
• Generation of proton gradient across inner mitochondrial membrane
• Proton motive force
• ATP synthesis by oxidative phosphorylation
• Structure of ATP synthase (Complex V)
• Rotary mechanism of ATP synthase
• Control of respiration rate
• Coupling between oxidation and phosphorylation
• Respiratory chain inhibitors
• Sites of action of respiratory inhibitors
• Mechanism of uncouplers
• Physiological role of uncouplers in heat production
. Oxidation of reducing equivalents (NADH, FADH₂) via electron transport chain