Topic 32 – Glycolysis, Pyruvate Metabolism and Gluconeogenesis

Curriculum Coverage

Biochemistry

• Definition of glycolysis

• Glucose transport via GLUT transporters

• Reactions of glycolysis

• NADH shuttle systems

• Energetics of glycolysis

• Fate of pyruvate

• Types of glycolysis
• Anaerobic glycolysis

• Key enzymes of glycolysis

• Regulation of glycolysis

• Glycolysis in RBC

• Glycolysis in cancer cells

• Clinical disorders of glycolysis

• Conversion of pyruvate into acetyl CoA

• Enzymes of PDH complex

• Coenzymes of PDH complex

• Reaction sequence of PDH complex

• Regulation of PDH

• Clinical aspects of PDH deficiency

• Definition of gluconeogenesis

• Organs of gluconeogenesis

• Cellular location

• Substrates of gluconeogenesis

• Three bypass reactions

• Gluconeogenesis from fatty acids

• Cori cycle

• Regulation of gluconeogenesis

• Key enzymes of gluconeogenesis

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