This topic integrates synthesis and breakdown of fatty acids — the core of lipid metabolism.
Curriculum Coverage
Biochemistry
Fatty Acid Synthesis
• Organs where fatty acid synthesis occurs
• Subcellular site of fatty acid synthesis
• Source of acetyl CoA
• Transport of acetyl CoA from mitochondria
• Steps of fatty acid synthesis
• Enzymes involved
• Fatty acid synthase
• Structure and components
• Product of fatty acid synthase
• Fate of fatty acid
• Regulation of fatty acid synthesis
• Why fatty acids cannot convert to glucose
• Elongation of fatty acids
• Desaturation of fatty acids
• Regulation of elongation and desaturation
Fatty Acid Oxidation
• Mobilization of fats from adipose tissue
• Methods of fatty acid oxidation
• Beta oxidation stages
• Reactions of beta oxidation
• ATP yield from palmitic acid
• Oxidation of odd-chain fatty acids
• Genetic deficiencies
- MCAD deficiency
- CAT deficiency
• Comparison of fatty acid synthesis vs oxidation