Topic 40 – Eicosanoid Metabolism and Inflammatory Mediators

This topic focuses on biochemical mediators involved in inflammation.


Curriculum Coverage

Biochemistry

• Definition of eicosanoids

• Classes of eicosanoids

• Cyclo-oxygenase pathway

• COX isomers

• COX inhibition

• Role of aspirin

• NSAIDs adverse effects

• Steroid adverse effects

• Catabolism of prostanoids

• Lipoxygenase pathway

• Leukotriene synthesis

• Leukotriene inhibition

• Leukotriene receptor antagonists

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