Topic 41 – Cholesterol and Bile Acid Metabolism

This topic integrates cholesterol metabolism with bile formation.

Curriculum Coverage

Biochemistry

• Sites of cholesterol synthesis

• Source of cholesterol

• Steps of cholesterol synthesis

• Regulation of cholesterol synthesis

• HMG-CoA reductase inhibitors

• Degradation of cholesterol

• Bile acid synthesis

• Conjugation of bile acids

• Bile salt formation

• Micelle formation

• Enterohepatic circulation

• Role of bile acid sequestrants

• Dietary fiber effects

• Regulation of bile acid synthesis