Course Content
🔬 Station 1 — Microscopic Identification of Acute Inflammation
Learning Outcomes Identify inflammatory cells on a provided microscopic slide. Identify the histopathological changes of acute appendicitis. Relate the demonstrated microscopic findings to acute inflammation.
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Microscopic Identification of Acute Inflammation
🔬 Station 2 — Microscopic Identification of Chronic and Granulomatous Inflammation
Learning Outcomes Identify the morphological changes of chronic inflammation in a provided specimen/slide. Identify the characteristic cells and their arrangement in a granuloma. Distinguish the demonstrated chronic inflammatory pattern from acute inflammation when asked.
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Microscopic Identification of Chronic and Granulomatous Inflammation
🔬 Station 3 — Identification of Granulation Tissue
Learning Outcomes Identify granulation tissue on a provided histopathology slide/image. Identify its characteristic microscopic features. Distinguish granulation tissue from granulomatous inflammation when asked.
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Identification of Granulation Tissue
🧪 Station 4 — Performance and Interpretation of Bacterial Biochemical Tests
Learning Outcomes Perform the bacterial biochemical test provided at the station using the appropriate technique. Observe and interpret the test result. Report the test as positive or negative based on the demonstrated reaction.
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Performance and Interpretation of Bacterial Biochemical Tests
🧫 Station 5 — Identification of Culture Media and Hemolysis on Blood Agar
Learning Outcomes Identify the provided microbiological culture medium. Recognize blood agar, mannitol salt agar, chocolate medium or Cary-Blair transport medium when presented. Identify the demonstrated pattern of hemolysis on blood agar.
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Identification of Culture Media and Hemolysis on Blood Agar
🚑 Station 6 — Demonstration of Gastric Lavage
Learning Outcomes Demonstrate the sequence of steps involved in gastric lavage using the provided model/manikin and equipment. Demonstrate safe handling and appropriate procedural sequence. State the essential precaution(s) relevant to the procedure when asked.
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Demonstration of Gastric Lavage
💊 Station 7 — Prescription Writing for Common Infectious Diseases Acute Tonsillitis / Malaria
Learning Outcomes Construct a complete prescription for the supplied infectious-disease scenario. Select appropriate medication with dose, route, frequency and duration. Demonstrate essential principles of safe and rational prescription writing.
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Prescription Writing for Common Infectious Diseases Acute Tonsillitis / Malaria
🦴🔍 Station 8 — Forensic Personal Identification: Bone or Hair/Fibre
Learning Outcomes Determine human sex from a provided bone or identify human hair microscopically, according to the station material. Identify the relevant distinguishing characteristics supporting the conclusion. Differentiate human hair from fibre when that specimen is provided.
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Forensic Personal Identification: Bone or Hair/Fibre
🦠 Station 9 — Laboratory Identification of Common Parasites
Learning Outcomes Identify the supplied parasite/specimen from a laboratory slide or specimen. Recognize the characteristic diagnostic form demonstrated. State the identifying feature supporting the diagnosis.
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Laboratory Identification of Common Parasites
🌍 Station 10 — Identification of Communicable Disease Models and Prevention
Learning Outcomes Identify the communicable disease represented by the provided model. Identify the important signs/features demonstrated by the model. State the major complication(s) and relevant preventive measures.
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Identification of Communicable Disease Models and Prevention
🧪🔬 AIM OSPE/OSCE Lab — Infection & Inflammation Module | 3rd Year MBBS
AIM OSCE / OSPE • MBBS

🔬 Station 3 — Identification of Granulation Tissue

Rapid Revision • Practical Skills • Viva

🎯 Task

CANDIDATE TASK

You are shown an H&E-stained histopathology slide/image from a tissue-repair specimen. Identify the tissue, state its characteristic microscopic features, and distinguish it from granulomatous inflammation when asked.

⚡ Model Station Answer What to say in the exam

Identification: This is granulation tissue.
Key features: Numerous newly formed thin-walled capillaries, proliferating fibroblasts and loose edematous connective tissue with inflammatory cells.
Microscopy: The capillaries are lined by plump endothelial cells, with fibroblasts and early collagen deposition between them.
Distinction: Granulomatous inflammation instead shows organized aggregates of epithelioid macrophages, often with multinucleated giant cells and surrounding lymphocytes.

🔎 Stepwise Procedure / Approach

  1. Start at low power. Assess the overall architecture and look for a loose, highly vascular reparative tissue pattern.
  2. Assess vascularity. Look for numerous newly formed small capillaries distributed throughout the tissue.
  3. Examine the vessels. Identify thin vascular channels lined by relatively plump endothelial cells.
  4. Look between the vessels. Identify proliferating spindle-shaped fibroblasts within a loose edematous extracellular matrix.
  5. Identify the inflammatory component. Mixed inflammatory cells, particularly macrophages with variable lymphocytes and neutrophils, may be present.
  6. Search for maturation. Increasing collagen deposition may be visible as the reparative tissue evolves toward scar formation.
  7. Exclude a granuloma pattern. Absence of a compact epithelioid-histiocyte aggregate with characteristic giant cells supports granulation tissue rather than granulomatous inflammation.
  8. State the identification clearly. Correlate the vascular proliferation, fibroblasts and loose inflammatory stroma and identify the slide as granulation tissue.

🖼️ Visual Learning

VISUAL 1

Granulation Tissue — Microscopic Recognition and Granuloma Comparison

 

🎥 Practical Video

🎥 Practical Demonstration — Skin: Granulation Tissue
Source: NUS Pathweb — National University of Singapore

A pathology slide demonstration showing the microscopic appearance of granulation tissue in skin and helping students recognize its practical histological features.
▶ Watch Practical Video

📝 Important Viva Questions

Q1. What is granulation tissue?
Answer: It is newly formed vascular connective tissue produced during tissue repair, composed mainly of proliferating capillaries, fibroblasts and inflammatory cells in a loose extracellular matrix.
Q2. What are the major microscopic features of granulation tissue?
Answer: Numerous newly formed capillaries, proliferating fibroblasts, loose edematous stroma, inflammatory cells and gradually increasing collagen deposition.
Q3. Why does granulation tissue appear highly vascular?
Answer: Because angiogenesis produces numerous newly formed capillaries during the repair process.
Q4. Which connective-tissue cell is particularly important in granulation tissue?
Answer: The fibroblast, which proliferates and produces extracellular matrix and collagen during repair.
Q5. How does granulation tissue differ from a granuloma?
Answer: Granulation tissue is reparative tissue rich in capillaries and fibroblasts, whereas a granuloma is an organized collection of epithelioid macrophages, often with multinucleated giant cells and surrounding lymphocytes.
Q6. Is granulation tissue the same as a mature scar?
Answer: No. Granulation tissue is an early vascular phase of repair; with maturation, vascularity and cellularity decrease while collagen increases to form a scar.
Q7. What is a common examination mistake in this station?
Answer: Confusing granulation tissue with granulomatous inflammation. Look for capillaries and fibroblasts in granulation tissue versus epithelioid macrophage aggregates in a granuloma.
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