Course Content
Gastrointestinal System (GIT)-III — Final Year MBBS | Integrated Module
AIM · FINAL YEAR MBBS · GIT MODULE

KMU Past Paper Practice

Topic 1 — Dysphagia, Upper GI Bleeding & Vomiting Across the Lifespan

20 original KMU-style A-type Single Best Answer MCQs · Practice questions, not authenticated past-paper items

MCQ 1

Question:

A 68-year-old man develops coughing and a wet-sounding voice immediately after swallowing water following a recent stroke. His oxygen saturation falls during feeding. What is the safest immediate clinical decision?

Options:

Begin a normal solid diet
Request a gastric emptying study
Keep oral intake on hold pending swallowing assessment
Prescribe acid suppression and continue feeding
Arrange elective esophageal dilatation

Correct Answer:

Keep oral intake on hold pending swallowing assessment

Explanation:

Coughing, wet voice and desaturation suggest aspiration from impaired swallowing; oral intake should pause until safety is assessed.

MCQ 2

Question:

A 57-year-old man with a known esophageal narrowing suddenly cannot swallow even his saliva after eating meat. He is drooling but breathing comfortably. Which management is most appropriate?

Options:

Urgent therapeutic upper GI endoscopy
A trial of repeated large water swallows
Routine outpatient barium study
Oral proton pump inhibitor alone
Observation at home until morning

Correct Answer:

Urgent therapeutic upper GI endoscopy

Explanation:

Inability to handle secretions indicates complete esophageal obstruction and requires urgent endoscopic assessment and relief.

MCQ 3

Question:

A 51-year-old woman describes intermittent chest discomfort and dysphagia to both solids and liquids. Endoscopy shows no structural lesion. Which finding would most strongly support a primary esophageal motility problem?

Options:

A fixed irregular mucosal mass
An ulcerated distal esophageal stricture
A retained foreign object
A narrowing caused by extrinsic tumor
Abnormal coordinated contractions on manometry

Correct Answer:

Abnormal coordinated contractions on manometry

Explanation:

After excluding obstruction, manometry can demonstrate disordered esophageal contractions causing dysphagia.

MCQ 4

Question:

A 62-year-old man reports painful swallowing, retrosternal discomfort and reduced oral intake. Examination reveals oral candidiasis and he uses an immunosuppressive medicine. Which interpretation best fits his new symptom?

Options:

A lower intestinal transit problem
Inflammatory or infective esophageal disease
A primary gastric emptying disorder
A mechanical colonic obstruction
A functional gallbladder disorder

Correct Answer:

Inflammatory or infective esophageal disease

Explanation:

Odynophagia accompanied by oral candidiasis and immunosuppression suggests esophageal inflammation or infection rather than isolated motility dysfunction.

MCQ 5

Question:

A 66-year-old patient reports progressive swallowing difficulty. A clinician initially considers a functional swallowing disorder, but finds marked unintentional weight loss and a palpable supraclavicular node. What is the most appropriate interpretation?

Options:

Symptoms are typical of uncomplicated reflux
The patient can be managed without investigation
The node makes swallowing dysfunction unlikely
Alarm features require expedited investigation for malignancy
Reassurance is sufficient if oral fluids are tolerated

Correct Answer:

Alarm features require expedited investigation for malignancy

Explanation:

Progressive dysphagia with weight loss and lymphadenopathy are alarm features that warrant urgent structural evaluation.

MCQ 6

Question:

A 74-year-old man arrives after vomiting blood and appears pale. Despite an apparently normal first hemoglobin result, he is tachycardic, cool peripherally and has a narrow pulse pressure. What explains the apparent laboratory–clinical mismatch?

Options:

An early hemoglobin level can underestimate acute blood loss
Hemoglobin rises immediately during major hemorrhage
Tachycardia rules out gastrointestinal hemorrhage
A normal hemoglobin proves adequate circulating volume
Peripheral coolness indicates isolated iron deficiency

Correct Answer:

An early hemoglobin level can underestimate acute blood loss

Explanation:

In early acute hemorrhage, whole blood is lost before dilution occurs, so the initial hemoglobin may not reflect severity.

MCQ 7

Question:

A 60-year-old man with hematemesis has raised urea relative to creatinine while reporting no urinary symptoms. Which mechanism may contribute to this laboratory pattern?

Options:

Reduced intestinal absorption of nitrogen
Reduced hepatic synthesis of urea
Digestion and absorption of blood proteins in the gut
Isolated potassium loss from vomiting
Increased elimination of urea in stool

Correct Answer:

Digestion and absorption of blood proteins in the gut

Explanation:

Digested blood proteins increase nitrogen absorption and urea generation; volume depletion may add a prerenal component.

MCQ 8

Question:

An older woman taking a nonsteroidal anti-inflammatory drug is admitted with suspected ulcer bleeding. Besides stabilizing her and arranging endoscopy, which modification directly addresses an avoidable contributor to the injury?

Options:

Increase the anti-inflammatory drug dose
Withhold the offending NSAID and review safer analgesia
Add a laxative to improve bowel transit
Begin empiric antifungal medication
Start a prokinetic as sole treatment

Correct Answer:

Withhold the offending NSAID and review safer analgesia

Explanation:

NSAIDs impair prostaglandin-mediated mucosal protection; stopping the culprit drug reduces ongoing injury and rebleeding risk.

MCQ 9

Question:

A 47-year-old man with cirrhosis is admitted with suspected portal-hypertensive bleeding. Endoscopy is being arranged. Which additional early measure reduces an important infection-related complication?

Options:

Routine oral antacids
Immediate elective colonoscopy
Long-term iron therapy alone
Empiric corticosteroid treatment
Antibiotic prophylaxis during the acute bleed

Correct Answer:

Antibiotic prophylaxis during the acute bleed

Explanation:

Cirrhotic patients with upper GI bleeding have increased bacterial infection risk; early antibiotic prophylaxis improves outcomes.

MCQ 10

Question:

A 59-year-old woman presents with syncope and melena. Her blood pressure is 88/56 mmHg and she remains confused after a brief initial fluid infusion. A relative asks why endoscopy has not begun. What is the best clinical priority?

Options:

Provide oral fluid replacement first
Schedule an outpatient endoscopy
Administer an antiemetic and discharge
Continue urgent resuscitation and stabilize before endoscopy
Perform an elective barium swallow

Correct Answer:

Continue urgent resuscitation and stabilize before endoscopy

Explanation:

In unstable GI bleeding, restoring airway and circulation and arranging urgent definitive care takes priority over immediate endoscopy without stabilization.

MCQ 11

Question:

A newborn begins vomiting on day 1 of life. The vomitus is green, but the abdomen is not visibly distended. Which interpretation is safest?

Options:

The absence of distension excludes intestinal obstruction
Bilious vomiting requires urgent exclusion of surgical obstruction
The pattern proves uncomplicated milk intolerance
Normal stools exclude malrotation
Physiological reflux usually produces green vomit

Correct Answer:

Bilious vomiting requires urgent exclusion of surgical obstruction

Explanation:

Bilious vomiting can indicate obstruction distal to the ampulla; lack of distension does not reliably exclude a surgical emergency.

MCQ 12

Question:

A 5-week-old infant has several days of vomiting and fewer wet nappies. Examination reveals a sunken fontanelle, prolonged capillary refill and lethargy. Which assessment best determines the immediate treatment priority?

Options:

Number of feeds offered yesterday
Presence of an abdominal skin rash
Birth order within the family
History of maternal reflux symptoms
Clinical perfusion and dehydration severity

Correct Answer:

Clinical perfusion and dehydration severity

Explanation:

Signs of poor perfusion and severe dehydration indicate urgent fluid resuscitation before detailed etiological treatment.

MCQ 13

Question:

A 7-week-old infant with repeated vomiting has low serum chloride and high bicarbonate. After initial stabilization, which additional measurement is most useful for monitoring safe correction of the disturbance?

Options:

Repeat serum electrolytes and acid–base status
Serum cholesterol alone
Maternal thyroid antibodies
Fecal occult blood alone
Serum tumor markers

Correct Answer:

Repeat serum electrolytes and acid–base status

Explanation:

Serial electrolytes and bicarbonate establish whether vomiting-related alkalosis and salt deficits are being corrected.

MCQ 14

Question:

A thriving 4-month-old infant frequently brings up small amounts of milk. Parents ask whether to position the child prone during sleep to prevent regurgitation. Which advice best balances feeding management with safety?

Options:

Recommend prone sleeping after every feed
Elevate the mattress using loose pillows
Use age-appropriate feeding adjustments while maintaining supine sleep
Stop all feeds for prolonged periods
Begin routine surgical referral

Correct Answer:

Use age-appropriate feeding adjustments while maintaining supine sleep

Explanation:

Simple regurgitation can be managed with feeding advice; infants should still sleep supine on a flat, firm surface to reduce sleep-related death risk.

MCQ 15

Question:

A neonate with ongoing vomiting becomes progressively distended and lethargic. The surgical team requests gastric decompression while arranging urgent assessment. What is the main purpose of the nasogastric tube in this context?

Options:

To cure the congenital lesion
To confirm pyloric muscle thickness
To replace intravenous fluid therapy
To reduce gastric accumulation and aspiration risk
To exclude intestinal ischemia

Correct Answer:

To reduce gastric accumulation and aspiration risk

Explanation:

Nasogastric decompression reduces accumulated gastric contents while resuscitation and definitive evaluation proceed; it does not correct obstruction.

MCQ 16

Question:

A pregnant woman at 10 weeks reports persistent vomiting and abdominal discomfort. She has significant dysuria, fever and costovertebral angle tenderness. What should guide the next decision?

Options:

Assume all symptoms are caused by hyperemesis
Investigate for urinary infection in addition to treating vomiting
Discontinue assessment because early-pregnancy vomiting is common
Delay urine testing until after the first trimester
Treat with dietary advice alone

Correct Answer:

Investigate for urinary infection in addition to treating vomiting

Explanation:

Fever, dysuria and flank tenderness suggest urinary tract infection, an alternative or additional cause needing prompt assessment.

MCQ 17

Question:

A patient admitted with hyperemesis gravidarum has persistent inability to eat and substantial weight loss. Vomiting is improving after fluid and antiemetic treatment, but oral nutrition remains poor. What additional care principle is most appropriate?

Options:

Continue fluids without monitoring nutritional intake
Prescribe prolonged complete fasting
Discharge solely because vomiting frequency declined
Stop antenatal follow-up until weight returns
Assess nutrition and arrange graded intake or further support

Correct Answer:

Assess nutrition and arrange graded intake or further support

Explanation:

Successful treatment includes restoration of adequate nutrition, not merely reduction in vomiting frequency.

MCQ 18

Question:

A 25-year-old at 9 weeks’ gestation has severe vomiting. An ultrasound shows a multiple pregnancy. Which interpretation most appropriately connects this finding with the presenting problem?

Options:

Higher pregnancy-related hCG levels may contribute to severe nausea and vomiting
Multiple pregnancy excludes hyperemesis gravidarum
Vomiting must be due to bowel obstruction
The ultrasound confirms primary adrenal insufficiency
Multiple pregnancy prevents electrolyte disturbance

Correct Answer:

Higher pregnancy-related hCG levels may contribute to severe nausea and vomiting

Explanation:

Multiple gestation is associated with higher hCG exposure, which can contribute to pregnancy-related nausea and hyperemesis.

MCQ 19

Question:

A pregnant patient recovering from severe vomiting asks why her pulse, urine output and blood chemistry are being checked even though nausea is improving. Which explanation best connects monitoring to safe care?

Options:

Symptoms alone measure renal perfusion reliably
Electrolyte values are unrelated to prolonged vomiting
Clinical improvement can precede full correction of fluid and electrolyte deficits
Monitoring is used only to diagnose fetal anomalies
Routine observation replaces nutritional reassessment

Correct Answer:

Clinical improvement can precede full correction of fluid and electrolyte deficits

Explanation:

Improved nausea does not establish correction of dehydration, renal hypoperfusion or electrolyte abnormalities; these need reassessment.

MCQ 20

Question:

A 29-year-old woman treated for hyperemesis can drink small amounts but still becomes dizzy on standing and has passed very little urine. She requests discharge because vomiting is less frequent. Which disposition is most appropriate?

Options:

Discharge after advising complete fluid restriction
Discharge if the next meal is tolerated
Provide reassurance without reassessing vitals
Continue supervised hydration and reassess clinical stability
Replace intravenous fluids with iron tablets

Correct Answer:

Continue supervised hydration and reassess clinical stability

Explanation:

Orthostatic symptoms and oliguria suggest unresolved volume depletion; safe discharge requires stable hydration and ability to maintain intake.

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