📘Step 1. Curriculum Coverage
🔬 Pathology
General Approach to Anemia
- Discuss the physiological basis of anemia.
- Classify anemias according to the underlying mechanism.
- Describe the pathogenesis of blood-loss anemia.
Iron-Deficiency Anemia
- Discuss the pathophysiological mechanism of iron-deficiency anemia.
- Describe its clinical course and morphological changes.
- Explain the laboratory investigations used for diagnosis.
Megaloblastic Anemia
- Describe megaloblastic anemia.
- Explain its pathogenesis with reference to vitamin B12 and folic-acid deficiency.
- Discuss morphological changes involving RBCs, WBCs and platelets.
- Explain the diagnostic approach to determining the underlying cause.
Aplastic Anemia
- Enumerate the causes of aplastic anemia.
- Describe its pathophysiology.
- Explain the diagnostic approach to aplastic anemia.
💊 Pharmacology
Drugs Used in Anemia
- Classify drugs used in anemia.
- Describe the pharmacokinetics of iron.
- Describe oral and parenteral iron preparations.
- Describe adverse effects of iron therapy.
- Describe treatment of iron toxicity.
- Describe oral and parenteral preparations of cyanocobalamin.
- Describe the clinical uses of vitamin B12.
- Describe the clinical uses of folic acid.
- Explain the pharmacological rationale for combining cyanocobalamin, folic acid and iron.
🌍 Community Medicine
Nutritional Anemia in Pakistan
- Classify nutritional anemias.
- Describe populations at risk of nutritional anemia in Pakistan.
- Describe risk factors for nutritional anemias.
- Describe the most prevalent anemias affecting the population of Pakistan and identify vulnerable populations and their risk factors.
- Explain effective public-health strategies for prevention of nutritional anemias in Pakistan.
🔁 Basic Science Spiral Link
Erythropoiesis and Red Cell Indices
- Discuss the steps of erythropoiesis.
- Correlate erythropoiesis with red cell indices and their clinical implications.
