📘Step 1. Curriculum Coverage
🔬 Pathology / Immunology
Allergy and Hypersensitivity
- Describe the pathophysiology of allergy and hypersensitivity with examples.
- Compare immediate and delayed hypersensitivity reactions.
- Enlist diseases associated with hypersensitivity reactions.
Immune Tolerance and Transplantation
- Describe immune tolerance.
- Explain immunological unresponsiveness to self-antigens.
- Describe types of immunological tolerance.
- Explain mechanisms of graft rejection.
- Explain graft-versus-host disease.
Autoimmune Diseases
- Define autoimmunity.
- Discuss the pathogenesis of autoimmune diseases.
- Explain factors leading to autoimmune disease.
Immunodeficiency
- Describe immunodeficiency.
- Differentiate autoimmune and immunodeficiency diseases.
- Classify congenital and acquired immunodeficiency disorders.
- Describe the pathogenesis of HIV infection.
💊 Pharmacology
Immunomodulating Drugs
- Classify immunomodulating drugs.
- Describe corticosteroids as immunosuppressant agents.
- Describe the mechanism of action, clinical uses and adverse effects of immunophilin ligands.
- Describe the mechanism of action, clinical uses and adverse effects of enzyme inhibitors.
- Describe the mechanism of action, clinical uses and adverse effects of cytotoxic agents used as immunosuppressants
- Describe immunosuppressive antibodies and their clinical uses and adverse effects.
- Describe monoclonal antibodies—their mechanism, uses and adverse effects.
- Describe immunostimulant drugs—their mechanism, uses and adverse effects.
- Discuss advantages and disadvantages of combinations of immunomodulating drugs.
- Discuss the rationale for immunomodulation and its therapeutic role in autoimmune disorders and malignancies.
