Course Content
Blood & Immunology Module — 3rd Year MBBS

📘Step 1. Curriculum Coverage

🔬 Pathology / Immunology

 

Allergy and Hypersensitivity

  • Describe the pathophysiology of allergy and hypersensitivity with examples.
  • Compare immediate and delayed hypersensitivity reactions.
  • Enlist diseases associated with hypersensitivity reactions.

Immune Tolerance and Transplantation

  • Describe immune tolerance.
  • Explain immunological unresponsiveness to self-antigens.
  • Describe types of immunological tolerance.
  • Explain mechanisms of graft rejection.
  • Explain graft-versus-host disease.

Autoimmune Diseases

  • Define autoimmunity.
  • Discuss the pathogenesis of autoimmune diseases.
  • Explain factors leading to autoimmune disease.

Immunodeficiency

  • Describe immunodeficiency.
  • Differentiate autoimmune and immunodeficiency diseases.
  • Classify congenital and acquired immunodeficiency disorders.
  • Describe the pathogenesis of HIV infection.

💊 Pharmacology

 

Immunomodulating Drugs

  • Classify immunomodulating drugs.
  • Describe corticosteroids as immunosuppressant agents.
  • Describe the mechanism of action, clinical uses and adverse effects of immunophilin ligands.
  • Describe the mechanism of action, clinical uses and adverse effects of enzyme inhibitors.
  • Describe the mechanism of action, clinical uses and adverse effects of cytotoxic agents used as immunosuppressants
  • Describe immunosuppressive antibodies and their clinical uses and adverse effects.
  • Describe monoclonal antibodies—their mechanism, uses and adverse effects.
  • Describe immunostimulant drugs—their mechanism, uses and adverse effects.
  • Discuss advantages and disadvantages of combinations of immunomodulating drugs.
  • Discuss the rationale for immunomodulation and its therapeutic role in autoimmune disorders and malignancies.

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