Course Content
Ophthalmology (Eye) Module β€” 4th Year MBBS
AIM β€’ EXAM ARENA

KMU Past Paper Practice

πŸ“˜ Topic 14 β€” Childhood Blindness, Leukocoria & Amblyopia
4th Year MBBS β€’ Ophthalmology πŸ‘οΈ β€’ 20 A-type Single Best Answer MCQs

MCQ 1

Question:

An 18-month-old child is brought with unilateral leukocoria. Initial examination suggests a posterior-segment mass, but the child is distressed and does not permit adequate examination of either fundus. What is the most appropriate next step to complete the ocular assessment?

Options:

Cycloplegic refraction without further fundus assessment
Observation until the child is old enough to cooperate
Examination under anaesthesia with dilated fundus examination
Routine colour vision testing in both eyes
Pinhole visual acuity testing before further assessment
Correct Answer:
Examination under anaesthesia with dilated fundus examination
Explanation: A young uncooperative child with suspected serious intraocular disease may require examination under anaesthesia so both eyes can be examined completely and accurately.

MCQ 2

Question:

A 2-year-old child is evaluated for a recently noticed convergent squint. Fundus examination reveals a retinal tumour involving the central retina. The parents had not noticed leukocoria. What best explains the ocular deviation in this child?

Options:

Loss of central visual fixation from tumour involvement
Mechanical shortening of the medial rectus muscle
Raised pressure causing paralysis of accommodation
Inflammation of the extraocular muscle tendons
Corneal edema producing excessive convergence
Correct Answer:
Loss of central visual fixation from tumour involvement
Explanation: A retinal tumour affecting central vision can impair fixation in the involved eye, allowing ocular misalignment and strabismus to develop.

MCQ 3

Question:

A child with retinoblastoma has several intraocular tumours in an eye with useful visual potential. Systemic chemotherapy is started and subsequent examination shows substantial reduction in tumour size. What is the principal purpose of this approach?

Options:

To correct the associated refractive error
To prevent physiological growth of the globe
To improve drainage through the trabecular meshwork
To restore transparency of the crystalline lens
To reduce tumour volume and facilitate focal treatment
Correct Answer:
To reduce tumour volume and facilitate focal treatment
Explanation: Chemotherapy may shrink retinoblastoma and make residual disease suitable for focal eye-preserving treatment such as laser or cryotherapy.

MCQ 4

Question:

A child with hereditary retinoblastoma is being considered for different tumour-control strategies. The team wishes to restrict radiotherapy when effective alternatives are available. Which long-term concern most strongly supports this decision?

Options:

Progressive loss of accommodation in both eyes
Increased risk of radiation-associated second malignancy
Permanent obstruction of aqueous humour production
Development of bilateral congenital cataract in infancy
Failure of retinal calcification to remain detectable
Correct Answer:
Increased risk of radiation-associated second malignancy
Explanation: Children with hereditary RB1 abnormalities have increased susceptibility to additional malignancies, making unnecessary radiation exposure particularly undesirable.

MCQ 5

Question:

A 3-year-old child with known retinoblastoma was lost to follow-up. He now returns with marked forward displacement of the affected eye and deterioration in vision. What does this new finding most strongly suggest?

Options:

Resolution of the intraocular tumour
Development of isolated refractive amblyopia
Formation of an uncomplicated lens opacity
Progression to advanced extraocular disease
Spontaneous reopening of aqueous outflow
Correct Answer:
Progression to advanced extraocular disease
Explanation: Proptosis in a child with untreated retinoblastoma is a serious sign suggesting tumour extension beyond the globe into the orbit.

MCQ 6

Question:

During routine examination of a 6-month-old infant, a small localized opacity is seen at the front pole of the crystalline lens. The remainder of the lens is clear. Which morphological type is present?

Options:

Nuclear cataract
Anterior polar cataract
Lamellar cataract
Sutural cataract
Membranous cataract
Correct Answer:
Anterior polar cataract
Explanation: An anterior polar cataract is a localized opacity at the anterior pole of the lens and may have limited visual effect when small.

MCQ 7

Question:

A 4-year-old child undergoing eye examination is found to have fine opacities following the normal Y-shaped lines within the lens. Visual acuity is only mildly affected. Which type of congenital cataract best matches this appearance?

Options:

Total cataract
Nuclear cataract
Posterior polar cataract
Lamellar cataract
Sutural cataract
Correct Answer:
Sutural cataract
Explanation: Sutural cataracts follow the characteristic Y-shaped sutures formed by the arrangement of lens fibres.

MCQ 8

Question:

An infant develops congenital lens opacity despite an otherwise structurally normal anterior segment. Which alteration most directly converts the normally transparent lens into an opaque optical medium?

Options:

Disruption of the orderly arrangement of lens fibres and proteins
Excess aqueous secretion by the ciliary processes
Progressive enlargement of the optic nerve head
Loss of pigmentation from the retinal pigment epithelium
Contraction of the extraocular rectus muscles
Correct Answer:
Disruption of the orderly arrangement of lens fibres and proteins
Explanation: Lens transparency depends on highly ordered fibres and proteins; disruption increases light scattering and produces cataract.

MCQ 9

Question:

A child treated surgically for congenital cataract has a clear visual axis during follow-up. One year later, visual acuity has fallen and the child’s previous spectacle correction no longer provides a clear image. What is the most appropriate next step?

Options:

Perform retinal cryotherapy
Start pressure-lowering surgery immediately
Discontinue all optical correction
Repeat refraction and update optical correction
Delay reassessment until visual development is complete
Correct Answer:
Repeat refraction and update optical correction
Explanation: Refractive requirements change as the child’s eye develops, so long-term cataract follow-up includes repeated refraction and appropriate optical rehabilitation.

MCQ 10

Question:

An infant with congenital glaucoma has progressive enlargement of the optic-disc cup during follow-up. Which pathological process most directly accounts for this change?

Options:

Swelling of the crystalline lens fibres
Accumulation of lipid beneath the retina
Pressure-related injury to retinal ganglion-cell axons
Fibrosis of the extraocular muscle insertions
Obstruction of the nasolacrimal drainage system
Correct Answer:
Pressure-related injury to retinal ganglion-cell axons
Explanation: Persistently raised intraocular pressure damages retinal ganglion-cell axons at the optic nerve and produces glaucomatous disc cupping.

MCQ 11

Question:

A 5-month-old infant has primary congenital glaucoma with markedly raised intraocular pressure. Corneal clouding prevents adequate visualization of the anterior chamber angle. Which procedure can open the trabecular outflow pathway through an external approach?

Options:

Trabeculotomy
Lens aspiration
Retinal photocoagulation
Corneal transplantation
Optical penalization
Correct Answer:
Trabeculotomy
Explanation: Trabeculotomy opens the abnormal trabecular pathway externally and is useful when corneal haze prevents adequate visualization for an internal angle procedure.

MCQ 12

Question:

An infant with primary congenital glaucoma is started on pressure-lowering medication while arrangements are made for definitive treatment. How should the role of this medical therapy be interpreted?

Options:

It permanently corrects abnormal angle development
It replaces the need for visual rehabilitation
It reverses established optic-nerve damage
It serves mainly as an adjunct while surgery is planned
It restores normal corneal diameter after enlargement
Correct Answer:
It serves mainly as an adjunct while surgery is planned
Explanation: Primary congenital glaucoma is principally a surgical disease; medication can temporarily reduce pressure but does not correct developmental outflow obstruction.

MCQ 13

Question:

A 7-month-old infant is being assessed for suspected congenital glaucoma. The ophthalmologist wants to document both the chronic structural effect of raised pressure on the developing eye and evidence of neural damage. Which combination is most useful?

Options:

Colour vision testing and Amsler grid examination
Corneal diameter measurement and optic-disc examination
Schirmer testing and lacrimal sac examination
Retinoscopy and extraocular muscle testing
Pupil measurement and corneal sensation testing
Correct Answer:
Corneal diameter measurement and optic-disc examination
Explanation: Increased corneal diameter reflects pressure-related stretching of the infant eye, while optic-disc examination assesses glaucomatous neural damage.

MCQ 14

Question:

A 7-year-old child has reduced visual acuity despite a structurally normal eye. Refraction reveals significant uncorrected astigmatism that has been present since early childhood. There is no manifest squint. Which form of amblyopia best explains the deficit?

Options:

Strabismic amblyopia
Deprivation amblyopia
Anisometropic amblyopia
Isoametropic amblyopia
Meridional amblyopia
Correct Answer:
Meridional amblyopia
Explanation: Persistent uncorrected astigmatic blur during visual development can selectively impair vision in affected meridians, producing meridional amblyopia.

MCQ 15

Question:

A 6-year-old child has persistent reduction in best-corrected visual acuity. Amblyopia is suspected after refraction and alignment assessment. Why is a dilated fundus examination still essential before confirming the diagnosis?

Options:

To determine the exact pupil diameter
To measure the corneal refractive power
To exclude retinal or optic-nerve pathology
To demonstrate aqueous outflow obstruction
To assess the nasolacrimal drainage pathway
Correct Answer:
To exclude retinal or optic-nerve pathology
Explanation: Amblyopia should not be diagnosed until structural causes capable of explaining reduced vision, particularly retinal and optic-nerve disease, have been excluded.

MCQ 16

Question:

A 6-year-old child had longstanding ocular deviation with reduced acuity in one eye. Alignment is later corrected successfully, but visual acuity in that eye remains reduced. What is the most appropriate interpretation and management principle?

Options:

The persistent deficit proves retinal detachment is present
Visual treatment can stop because alignment is corrected
The eye should undergo glaucoma surgery next
Amblyopia therapy should continue despite corrected alignment
Removal of the crystalline lens is now required
Correct Answer:
Amblyopia therapy should continue despite corrected alignment
Explanation: Correcting strabismus removes the alignment problem but does not automatically reverse established abnormal visual development, so visual rehabilitation remains necessary.

MCQ 17

Question:

A child receiving occlusion therapy for unilateral amblyopia returns for follow-up. Vision in the treated eye has improved, but acuity in the previously better eye has started to decline. What is the most appropriate management principle?

Options:

Adjust occlusion therapy and reassess vision in both eyes
Increase occlusion without further visual monitoring
Perform bilateral cataract extraction
Begin retinal laser treatment in the better eye
Accept the new deficit as an expected permanent effect
Correct Answer:
Adjust occlusion therapy and reassess vision in both eyes
Explanation: Amblyopia treatment requires regular monitoring because excessive penalization of the better eye can itself reduce its visual function.

MCQ 18

Question:

A premature infant is clinically stable and ready for follow-up after neonatal care. The eyes appear externally normal and the parents ask why retinal examinations are still required. What is the main purpose of this surveillance?

Options:

To detect congenital cataract after visual maturity
To identify refractive error before retinal assessment
To detect retinopathy of prematurity before severe retinal damage develops
To prevent hereditary retinoblastoma by fundus examination
To diagnose glaucoma from the external appearance alone
Correct Answer:
To detect retinopathy of prematurity before severe retinal damage develops
Explanation: Appropriate retinal surveillance of at-risk premature infants allows retinopathy of prematurity to be recognized before progression to irreversible tractional retinal damage.

MCQ 19

Question:

A child-eye health programme identifies several children with permanent visual impairment from corneal scarring related to ocular injury, infection and nutritional problems. Which strategy best addresses the preventable component of this blindness?

Options:

Provide glaucoma surgery to all affected children
Use occlusion therapy as the sole intervention
Restrict assessment to children with leukocoria
Treat irreversible retinal disease with lens extraction
Prevent ocular injury and address infectious and nutritional causes early
Correct Answer:
Prevent ocular injury and address infectious and nutritional causes early
Explanation: Preventing injury and addressing treatable infectious or nutritional contributors can reduce avoidable corneal scarring and childhood visual loss.

MCQ 20

Question:

A 3-year-old child is referred after an abnormal white pupillary reflex is noted. Examination shows a clear cornea, clear anterior chamber and transparent crystalline lens. Which examination is now most important for localizing the source of the abnormal reflex?

Options:

Schirmer tear testing
Dilated fundus examination
Corneal sensation assessment
Extraocular muscle force testing
Near-point accommodation testing
Correct Answer:
Dilated fundus examination
Explanation: When the anterior segment and lens are clear, the source of leukocoria is likely posterior, making dilated retinal examination the key next localization step.
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