📘 Step 1 — Curriculum Coverage
This section outlines integrated curriculum components covered in this topic. Delete subjects that are not relevant to this topic.
🔹 Anatomy
- Paired and unpaired dural venous sinuses
• Structure and drainage of individual venous sinuse
🔹 Physiology
- Pain receptors and types of stimuli causing pain
• Types of pain
• Detailed pathway for pain
• Definition of analgesia
• Pain suppression system in brain and spinal cord
• Gate control theory
• Brain opiate system
• Primary hyperalgesia
• Secondary hyperalgesia
• Referred pain and its mechanism
• Clinical significance of referred pain with examples
• Causes of referred pain
• Causes of intracranial headache
• Causes of extracranial headache
• Correlation of headache with underlying pain mechanism
• Thermal receptors and their excitation
• Mechanism of stimulation of thermal receptors
• Transmission of thermal signals in nervous system
🔹 Biochemistry
- Definition of prostaglandins
• Role of prostaglandins in initiation of pain
🩺 Clinical Importance
- Headache as a clinical presentation of meningeal, vascular, intracranial and extracranial pain-sensitive structures
• Mechanistic link between prostaglandins, inflammation and pain
