Course Content
Multi-System Module — 3rd Year MBBS

📘Step 1. Curriculum Coverage

💊 Pharmacology

 

General Principles of Anticancer Therapy

  • Describe terms like cell cycle-specific drugs and cell cycle-nonspecific drugs.
  • Describe the role of P-glycoprotein in relation to the development of resistance to cytotoxic drugs.
  • Classify anticancer drugs.
  • Describe general adverse effects of anticancer drugs.

Alkylating Agents and Platinum Compounds

  • Describe the mechanism of action of alkylating agents.
  • Describe the clinical uses and adverse effects of Busulfan and Cyclophosphamide.
  • Describe the mechanism of action, clinical uses and adverse effects of Cisplatin.

Antimetabolites

  • Describe in general the mechanism of action of antimetabolites.
  • Describe the mechanism of action, clinical uses, adverse effects and contraindications of Methotrexate, Azathioprine, 6-Mercaptopurine and 5-Fluorouracil.
  • Describe the drug interaction of Azathioprine and 6-Mercaptopurine with Allopurinol.

Plant Alkaloids and Antitumor Antibiotics

  • Describe the natural source of plant alkaloids Vinblastine and Vincristine.
  • Describe the mechanism of action, clinical uses and adverse effects of Vinblastine and Vincristine.
  • Describe the mechanism of action, clinical uses and adverse effects of Doxorubicin, Daunorubicin, Dactinomycin and Bleomycin.

Hormonal Anticancer Therapy

  • Enlist the anticancer mechanism of action and uses of hormonal agents like Tamoxifen, Flutamide, Goserelin and Aminoglutethimide.

Cancer Chemotherapy Regimens and Toxicity

  • Enlist the drugs of choice for ALL, AML, CLL, CML, Hodgkin’s disease, Non-Hodgkin’s lymphoma, carcinoma breast, carcinoma lung, carcinoma prostate and carcinoma stomach.
  • Describe cancer treatment modalities (primary induction, adjuvant, neo-adjuvant and maintenance chemotherapy).
  • Describe the antidotes of Methotrexate, Cyclophosphamide and Doxorubicin toxicity.

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