📘Step 1. Curriculum Coverage
💊 Pharmacology
General Principles of Anticancer Therapy
- Describe terms like cell cycle-specific drugs and cell cycle-nonspecific drugs.
- Describe the role of P-glycoprotein in relation to the development of resistance to cytotoxic drugs.
- Classify anticancer drugs.
- Describe general adverse effects of anticancer drugs.
Alkylating Agents and Platinum Compounds
- Describe the mechanism of action of alkylating agents.
- Describe the clinical uses and adverse effects of Busulfan and Cyclophosphamide.
- Describe the mechanism of action, clinical uses and adverse effects of Cisplatin.
Antimetabolites
- Describe in general the mechanism of action of antimetabolites.
- Describe the mechanism of action, clinical uses, adverse effects and contraindications of Methotrexate, Azathioprine, 6-Mercaptopurine and 5-Fluorouracil.
- Describe the drug interaction of Azathioprine and 6-Mercaptopurine with Allopurinol.
Plant Alkaloids and Antitumor Antibiotics
- Describe the natural source of plant alkaloids Vinblastine and Vincristine.
- Describe the mechanism of action, clinical uses and adverse effects of Vinblastine and Vincristine.
- Describe the mechanism of action, clinical uses and adverse effects of Doxorubicin, Daunorubicin, Dactinomycin and Bleomycin.
Hormonal Anticancer Therapy
- Enlist the anticancer mechanism of action and uses of hormonal agents like Tamoxifen, Flutamide, Goserelin and Aminoglutethimide.
Cancer Chemotherapy Regimens and Toxicity
- Enlist the drugs of choice for ALL, AML, CLL, CML, Hodgkin’s disease, Non-Hodgkin’s lymphoma, carcinoma breast, carcinoma lung, carcinoma prostate and carcinoma stomach.
- Describe cancer treatment modalities (primary induction, adjuvant, neo-adjuvant and maintenance chemotherapy).
- Describe the antidotes of Methotrexate, Cyclophosphamide and Doxorubicin toxicity.
