Course Content
🧬 Theme I — Molecules and Bacteria
📘 Topic 1 — Foundations of Pharmacology, Drug Sources, Routes, Absorption and Bioavailability
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📘Step 1. Curriculum Coverage
📖 Step 2 — Problem-Based Integrated Learning Material
🧪Step 3 — Pre-Assessment, Diagnosis & Guided Reasoning
🧩Step 4 — Concept Integration
📝Step 5 — KMU Past Papers & Exam Learning
🎯Step 6 Post-Test Evaluation
🧠Step 7 Student Memory Support
📘 Topic 2 — Drug Distribution, Biotransformation and Pharmacogenetic Variation
0/7
📘Step 1. Curriculum Coverage
📖 Step 2 — Problem-Based Integrated Learning Material
🧪Step 3 — Pre-Assessment, Diagnosis & Guided Reasoning
🧩Step 4 — Concept Integration
📝Step 5 — KMU Past Papers & Exam Learning
🎯Step 6 Post-Test Evaluation
🧠Step 7 Student Memory Support
📘 Topic 3 — Drug Excretion, Dosage Regimens and Pharmacokinetic Principles
0/7
📘Step 1. Curriculum Coverage
📖 Step 2 — Problem-Based Integrated Learning Material
🧪Step 3 — Pre-Assessment, Diagnosis & Guided Reasoning
🧩Step 4 — Concept Integration
📝Step 5 — KMU Past Papers & Exam Learning
🎯Step 6 Post-Test Evaluation
🧠Step 7 Student Memory Support
📘 Topic 4 — Pharmacodynamics, Drug Receptors and Dose–Response Relationships
0/7
📘Step 1. Curriculum Coverage
📖 Step 2 — Problem-Based Integrated Learning Material
🧪Step 3 — Pre-Assessment, Diagnosis & Guided Reasoning
🧩Step 4 — Concept Integration
📝Step 5 — KMU Past Papers & Exam Learning
🎯Step 6 Post-Test Evaluation
🧠Step 7 Student Memory Support
📘 Topic 5 — Drug Interactions, Altered Drug Response, Adverse Reactions and Drug Development
0/7
📘Step 1. Curriculum Coverage
📖 Step 2 — Problem-Based Integrated Learning Material
🧪Step 3 — Pre-Assessment, Diagnosis & Guided Reasoning
🧩Step 4 — Concept Integration
📝Step 5 — KMU Past Papers & Exam Learning
🎯Step 6 Post-Test Evaluation
🧠Step 7 Student Memory Support
📘 Topic 6 — Cellular Foundations, Bacterial Classification, Structure, Growth and Genetics
0/7
📘Step 1. Curriculum Coverage
📖 Step 2 — Problem-Based Integrated Learning Material
🧪Step 3 — Pre-Assessment, Diagnosis & Guided Reasoning
🧩Step 4 — Concept Integration
📝Step 5 — KMU Past Papers & Exam Learning
🎯Step 6 Post-Test Evaluation
🧠Step 7 Student Memory Support
📘 Topic 7 — Laboratory Diagnosis, Bacterial Pathogenesis and Prevention of Bacterial Disease
0/7
📘Step 1. Curriculum Coverage
📖 Step 2 — Problem-Based Integrated Learning Material
🧪Step 3 — Pre-Assessment, Diagnosis & Guided Reasoning
🧩Step 4 — Concept Integration
📝Step 5 — KMU Past Papers & Exam Learning
🎯Step 6 Post-Test Evaluation
🧠Step 7 Student Memory Support
📘 Topic 8 — Forensic Medicine, Medical Law, Professionalism and Patient Safety
0/7
📘Step 1. Curriculum Coverage
📖 Step 2 — Problem-Based Integrated Learning Material
🧪Step 3 — Pre-Assessment, Diagnosis & Guided Reasoning
🧩Step 4 — Concept Integration
📝Step 5 — KMU Past Papers & Exam Learning
🎯Step 6 Post-Test Evaluation
🧠Step 7 Student Memory Support
📘 Topic 9 — Foundations of ENT and Ophthalmology: Refractive and Lacrimal Disorders
0/7
📘Step 1. Curriculum Coverage
📖 Step 2 — Problem-Based Integrated Learning Material
🧪Step 3 — Pre-Assessment, Diagnosis & Guided Reasoning
🧩Step 4 — Concept Integration
📝Step 5 — KMU Past Papers & Exam Learning
🎯Step 6 Post-Test Evaluation
🧠Step 7 Student Memory Support
📘 Topic 10 — Health, Disease, Prevention, Primary Health Care and Health Systems
0/7
📘Step 1. Curriculum Coverage
📖 Step 2 — Problem-Based Integrated Learning Material
🧪Step 3 — Pre-Assessment, Diagnosis & Guided Reasoning
🧩Step 4 — Concept Integration
📝Step 5 — KMU Past Papers & Exam Learning
🎯Step 6 Post-Test Evaluation
🧠Step 7 Student Memory Support
🧬 Theme II — Aging and Death
📘 Topic 11 — Cellular Injury: Causes, Mechanisms and Subcellular Responses
0/7
📘Step 1. Curriculum Coverage
📖 Step 2 — Problem-Based Integrated Learning Material
🧪Step 3 — Pre-Assessment, Diagnosis & Guided Reasoning
🧩Step 4 — Concept Integration
📝Step 5 — KMU Past Papers & Exam Learning
🎯Step 6 Post-Test Evaluation
🧠Step 7 Student Memory Support
📘 Topic 12 — Cellular Adaptation, Necrosis, Apoptosis and Cellular Ageing
0/7
📘Step 1. Curriculum Coverage
📖 Step 2 — Problem-Based Integrated Learning Material
🧪Step 3 — Pre-Assessment, Diagnosis & Guided Reasoning
🧩Step 4 — Concept Integration
📝Step 5 — KMU Past Papers & Exam Learning
🎯Step 6 Post-Test Evaluation
🧠Step 7 Student Memory Support
📘 Topic 13 — Intracellular Accumulations, Steatosis, Pigments and Pathologic Calcification
0/7
📘Step 1. Curriculum Coverage
📖 Step 2 — Problem-Based Integrated Learning Material
🧪Step 3 — Pre-Assessment, Diagnosis & Guided Reasoning
🧩Step 4 — Concept Integration
📝Step 5 — KMU Past Papers & Exam Learning
🎯Step 6 Post-Test Evaluation
🧠Step 7 Student Memory Support
📘 Topic 14 — Thanatology, Diagnosis of Death and Death Certification
0/7
📘Step 1. Curriculum Coverage
📖 Step 2 — Problem-Based Integrated Learning Material
🧪Step 3 — Pre-Assessment, Diagnosis & Guided Reasoning
🧩Step 4 — Concept Integration
📝Step 5 — KMU Past Papers & Exam Learning
🎯Step 6 Post-Test Evaluation
🧠Step 7 Student Memory Support
📘 Topic 15 — Cataract: Pathogenesis, Types, Complications and Management
0/7
📘Step 1. Curriculum Coverage
📖 Step 2 — Problem-Based Integrated Learning Material
🧪Step 3 — Pre-Assessment, Diagnosis & Guided Reasoning
🧩Step 4 — Concept Integration
📝Step 5 — KMU Past Papers & Exam Learning
🎯Step 6 Post-Test Evaluation
🧠Step 7 Student Memory Support
📘 Topic 16 — Health Research, Health Systems and General Practice
0/7
📘Step 1. Curriculum Coverage
📖 Step 2 — Problem-Based Integrated Learning Material
🧪Step 3 — Pre-Assessment, Diagnosis & Guided Reasoning
🧩Step 4 — Concept Integration
📝Step 5 — KMU Past Papers & Exam Learning
🎯Step 6 Post-Test Evaluation
🧠Step 7 Student Memory Support
Foundation-II Module — 3rd Year MBBS

📘Step 1. Curriculum Coverage

💊 Pharmacology

 

Drug Distribution

  • Define distribution and redistribution of drugs.
  • Describe plasma protein binding and its clinical significance in disease.
  • Describe factors affecting drug distribution.

Volume of Distribution and Loading Dose

  • Define volume of distribution.
  • Enlist drugs with small and large volumes of distribution.
  • Apply the formula for calculating volume of distribution.
  • Explain its clinical significance.
  • Define loading dose.
  • Enlist drugs in which a loading dose is administered.
  • Apply the formula for calculating loading dose.

Physiological Barriers

  • Enlist important physiological barriers to drug transport.
  • Describe the blood-brain and placental barriers and their clinical significance.

Drug Biotransformation

  • Define biotransformation and xenobiotics.
  • Describe the objectives and fate of drugs following biotransformation.
  • Name the major sites of biotransformation.
  • Describe microsomal CYP450 and non-microsomal drug-metabolizing enzymes.
  • Describe phases and reactions of biotransformation.
  • Describe factors affecting drug biotransformation.

Pharmacogenetics and Enzyme Modulation

  • Define pharmacogenetics and pharmacogenomics.
  • Define idiosyncrasy with examples.
  • Describe genetic factors influencing drug biotransformation.
  • Define enzyme induction and enlist important enzyme inducers.
  • Explain the clinical significance of enzyme induction.
  • Define enzyme inhibition and enlist important enzyme inhibitors.
  • Explain the clinical significance of enzyme inhibition.

Describe suicide or mechanism-based inhibition with examples.

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