📘Step 1. Curriculum Coverage
🔬 Pathology
Foundations of Cell Injury
- Define disease, etiology, pathogenesis, morphology, cell injury and homeostasis in the context of pathology.
- Enumerate the different classes of pathology.
- Describe the causes of cell injury ranging from gross physical trauma to single-gene defects.
- Describe how the nature and severity of injury determine cellular responses.
Mechanisms of Cell Injury
- Describe the general biochemical mechanisms of cell injury.
- Describe ischemic and hypoxic cell injury.
- Describe ischemia-reperfusion injury.
- Describe free radical-induced cell injury.
- Describe chemical cell injury.
- Differentiate between reversible and irreversible cell injury.
- Describe the mechanisms, morphological changes, biochemical changes and functional alterations associated with reversible and irreversible cell injury.
Subcellular Responses to Injury
- Define phagocytosis, endocytosis, pinocytosis, autophagy and heterophagy.
Describe subcellular responses to injury, including lysosomal catabolism, heterophagy and autophagy.
