📘 Step 1. Curriculum Coverage

🔬 Pathology

• Explain the etiology and clinical features of hypercortisolism/Cushing syndrome.
• Explain its diagnostic work-up and management.
• Explain the etiology, clinical presentation, diagnostic work-up and management of primary hyperaldosteronism.
• Explain the etiology, clinical features, diagnostic work-up and management of adrenogenital syndrome.

💊 Pharmacology

• Describe relevant pharmacokinetic and pharmacodynamic principles of adrenocortical hormones and their antagonists.
• Classify glucocorticoids.
• Explain their mechanisms, pharmacological effects, clinical uses and adverse effects.
• Describe the dexamethasone suppression test.
• Enlist glucocorticoid antagonists and synthesis inhibitors.
• Explain the role, mechanism, uses and adverse effects of mifepristone, ketoconazole, metyrapone and aminoglutethimide in glucocorticoid excess.
• Explain the mechanism, clinical uses and adverse effects of spironolactone as an aldosterone antagonist.

🔁 Basic Science Spiral Link

• Explain the gross and microscopic structure of the adrenal gland.
• Explain synthesis and functions of adrenal cortical hormones and their regulation by the anterior pituitary.