📘 Step 1. Curriculum Coverage

Endocrine & Reproductive System Module — 4th Year MBBS

🔬 Pathology / Basic Science

Explain the gross and microscopic structure of the pituitary gland.
Explain the functions of anterior and posterior pituitary hormones and their regulation by the hypothalamus.
Explain the causes of hyperpituitarism.
Discuss the morphology and hormonal activity of pituitary adenomas, including prolactinomas, somatotroph, corticotroph and other functional adenomas.
Explain the clinical manifestations of different pituitary adenomas.
Describe the etiology and clinical manifestations of hypopituitarism.

Describe relevant pharmacokinetic and pharmacodynamic principles of pituitary hormones, their analogues and antagonists.
Describe old and newer sources of growth hormone.
Explain the mechanism of action, clinical uses and adverse effects of growth hormone.
Enlist growth-hormone antagonists.
Explain the clinical role of octreotide in acromegaly.
Describe the route, dosage and adverse effects of octreotide in acromegaly and gigantism.
Explain the mechanism of action, clinical uses and adverse effects of bromocriptine.

Explain the etiology, clinical features, investigations, treatment and complications of acromegaly and gigantism.
Discuss the etiology, clinical features, investigations and treatment of hyperprolactinemia.
Explain the etiology, clinical features, investigations and treatment of hypopituitarism and Sheehan syndrome.

Explain the role of height velocity, mid-parental height and target height in the evaluation of short stature.
Explain criteria used to differentiate causes of growth deficiency.
Discuss communication with patients and families and multidisciplinary management of growth disorders.
Discuss management of growth-hormone deficiency and other causes of short stature.

Explain the surgical management and complications of pituitary microadenomas and macroadenomas.