📘Step 1. Curriculum Coverage
💊 Pharmacology
Overview of Anti-Inflammatory Drugs
- Classify anti-inflammatory drugs.
- Describe the role of DMARDs and glucocorticoids as anti-inflammatory agents.
Non-Selective NSAIDs and Aspirin
- Classify NSAIDs.
- Differentiate non-selective COX inhibitors from selective COX-2 inhibitors based on mechanism of action.
- Name the prototype non-selective COX inhibitor.
- Describe the pharmacokinetics of aspirin.
- Describe the mechanism of action of aspirin as an antiplatelet, analgesic, antipyretic and anti-inflammatory agent.
- Give the dose of aspirin as an antiplatelet, analgesic/antipyretic and anti-inflammatory drug.
- Describe the clinical uses of NSAIDs.
- Describe the adverse effects of NSAIDs.
- Describe the drug treatment of aspirin poisoning.
- Describe the pharmacokinetics, with emphasis on dosage, duration of action and elimination, of diclofenac, ibuprofen, indomethacin, mefenamic acid and piroxicam in comparison with aspirin.
- Relate the pharmacokinetics and pharmacodynamics of NSAIDs to their clinical applications.
Selective COX-2 Inhibitors
- Describe the mechanism of action of selective COX-2 inhibitors.
- Describe their clinical uses.
- Describe their adverse effects.
- Describe the merits and demerits of selective COX-2 inhibitors compared with non-selective COX inhibitors.
Paracetamol (Acetaminophen)
- Describe the pharmacokinetics of paracetamol.
- Describe the mechanism of action of paracetamol.
- Describe its clinical uses.
- Describe its adverse effects.
- Give the therapeutic and fatal doses of paracetamol.
- Describe the drug treatment of paracetamol poisoning.