📘 Step 1 — Curriculum Coverage
This topic uses the AIM Learning Cycle to help MBBS students understand mitochondrial energy generation and ATP production.
🔹 Biochemistry
- Generation of proton gradient across inner mitochondrial membrane
• Proton motive force
• ATP synthesis by oxidative phosphorylation - Structure of ATP synthase (Complex V)
• Rotary mechanism of ATP synthase - Control of respiration rate
• Coupling between oxidation and phosphorylation - Respiratory chain inhibitors
• Sites of action of respiratory inhibitors - Mechanism of uncouplers
• Physiological role of uncouplers in heat production - Oxidation of reducing equivalents (NADH, FADH₂) via electron transport chain
